Selenium dioxide is the active ingredient in … Selenium is a mineral found in soil, water, and some foods. (Selenium yeast can be a safer form of to deliver the required selenium to a pet diet; according to one study Sodium Selenite is “2.94 times more toxic than Selenium Yeast”. USA.gov. But, sadly, the FDA has not yet approved the use of selenium yeast for use in cat food – only dog food has FDA approval.) Selenium Dioxide is a crystal or crystalline powder, usually found in either white or cream color. In cases of severe toxicity, cardiac and pulmonary symptoms may develop and ultimately lead to mortality. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. HHS Wei Sheng Wu Xue Bao. Most of the selenium in the body comes from the diet. A meta description is an HTML tag in the HTML code of your website, which allows you to customize a section of text that describes the page itself. Hydrogen selenide is the most acutely toxic selenium compound. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The most impressive finding was an orange-brown discoloration of the skin and all viscera, probably due to hemolysis and/or pigmentation related to ingestion of selenium dioxide. Selenium has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol . More soluble compounds, for example, sodium selenite, are more toxic than the less soluble elemental selenium, selenium sulfide, or selenium disulfide. 1986 Jun;31(2):87-92. doi: 10.1016/0379-0738(86)90192-1. Selenium toxicity is often caused by over-supplementation and can impact the human body in a number of ways. For “Repeated dose toxicity, inhalation”, an endpoint-specific literature search was performed (see IUCLID section 12) since in the ATSDR (2003) publication only studies on elemental selenium, selenium dioxide, and various other Se-compounds which are not considered adequate for risk assessment of Se-compounds that are covered by the current category (e.g. Excessive selenium causes brittle hair, hair loss, deformed nails, brittle nails, sloughing off of nails, tooth discoloration, tooth decay and mottled or discolored skin. Clipboard, Search History, and several other advanced features are temporarily unavailable. Selenium is used to treat or prevent selenium deficiency. Toxicity of selenium varies with valence state and water solubility of the compound in which it occurs. We describe the acute toxic effects of selenium, including exposure, blood, and urine levels associated with mortality. : AC193980000; AC193980100; AC193980500 CAS-No 7446-08-4 Synonyms Selenium dioxide Recommended Use Laboratory chemicals. Would you like email updates of new search results? 2013 Mar 28;5(4):1024-57. doi: 10.3390/nu5041024. Selenium dioxide can dissolve in water to make toxic selenium compounds. A major fraction of selenium in tissues was extractable by carbon disulfide, which seems to indicate the presence of elemental selenium and/or selenium disulfide. By continuing you agree to the use of cookies. * Because this is a MUTAGEN, handle it as a possible carcinogen--WITH EXTREME CAUTION. Concentrations of selenium in blood and urine samples in non-fatal cases are close to those observed in fatal cases. It is important for making many body processes work correctly. Many selenium compounds will cause intense burns of skin and mucous membranes, and chronic skin exposure to light concentrations of dust from certain compounds may produce dermatitis and paronychia. Stable to light and heat. * Selenium Oxide can affect you when breathed in and by passing through your skin. Mortality has been described after the ingestion of gun bluing solutions, which often contain selenous acid among other potentially toxic substances. The color of these substances is red and orange, respectively. For elucidation of the chemical nature of selenium in tissues, a new analytical method which was based on carbon disulfide extraction was developed. * Selenium Oxide can irritate and burn the eyes on contact. The published literature on the acute toxicity of oral selenium was gathered and reviewed. Attempts at resuscitation failed and the patient was pronounced dead. SAFETY DATA SHEET Creation Date 24-Nov-2010 Revision Date 19-Jan-2018 Revision Number 3 1. The most impressive finding was an orange-brown discoloration of the skin and all viscera, probably due to hemolysis and/or pigmentation related to ingestion of selenium dioxide. Selenium dioxide is a weak oxidizing agent and does not catch things on fire. Although selenium is an essential element for humans, acute toxicity has been reported after high oral exposure. 2007 Jun;47(3):554-7. Results: Reported symptoms and signs include abdominal symptoms, such as vomiting, diarrhea, pain, and nausea, as well as garlic-like odor on the breath. Please enable it to take advantage of the complete set of features! Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor. Common early symptoms of selenium toxicity and poisoning involve the hair and nail beds of the hands and feet. Matoba R, Kimura H, Uchima E, Abe T, Yamada T, Mitsukuni Y, Shikata I. Forensic Sci Int. Identification Product Name Selenium(IV) oxide Cat No. For evaluation of the therapeutic value of hemoperfusion in selenium poisoning in vitro hemoperfusion experiments were performed, which revealed only a moderate effect on selenium blood levels. A good oxidizing agent. Mortality has also been reported after the ingestion of other forms of selenium. The highest concentrations were found in pancreas, spleen, liver, and adipose tissue. An autopsy case of acute selenium (selenious acid) poisoning and selenium levels in human tissues. The type and severity of symptoms varies depending on the amount of chemical involved and the nature of the exposure. When possible, we differentiate between different selenium formulations. 14. Selenium dioxide is highly to moderately toxic, with oral LD50 values in rodents from 20 to 70 mg kg −1. Acute toxicity tests of selenium dioxide were conducted for 96 to 336 hr in intermittent-flow bioassay systems using six species of freshwater fish. This site needs JavaScript to work properly. It is used in small quantities to counteract the colour due to iron impurities and so to create (apparently) colourless glass. Some symptoms are more severe than others, but all represent a disruption in wellness. SELENIOUS ACID decomposes when heated to toxic and volatile selenium dioxide. Swallowing any more than a very tiny amount can cause selenium poisoning. Chemsrc provides Selenium dioxide(CAS#:7446-08-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Selenium toxicity causes the hair to become brittle, hair loss, deformed and brittle nails, sloughing off of the nails, discoloration of the teeth, tooth decay and discolored skin. | It is toxic in both inhaled or ingested situations and has a melting point of 340 degrees Celsius. COVID-19 is an emerging, rapidly evolving situation. Chemical poisoning -- Selenium Dioxide: Selenium Dioxide is a chemical used mainly in gun bluing solutions. Oxidizes many organic substances. Some of the selenium oxyhalides, such as selenium oxyfluoride (SeOF 2) and selenium oxychloride (SeOCl 2) have been used as specialty solvents. [40 CFR 261.24 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal … Carbon disulfide is a good solvent for non-polar selenium compounds like elemental selenium and selenium disulfide, but not for polar compounds like selenite and selenoproteins. * Selenium Oxide can irritate the skin causing a rash or burning feeling on contact. Articles of Selenium dioxide are included as well. Selenium blood and tissue levels were increased by a factor of 100-1000 as compared to normal. Rapidly absorbs dry hydrogen fluoride, hydrogen chloride, hydrogen bromide to form the corresponding selenium oxohalide. Uses advised against Food, drug, pesticide or biocidal product use. In larger quantities, it gives a deep ruby red colour. Selenium Dioxide is a one-dimensional solid polymer, with alternating selenium … Two hours after suicidal ingestion of an unknown amount of selenium dioxide, a 17-year-old male was admitted to hospital with asystolia and apnea. The latter can affect gastrointestinal absorption rates. Suicide by sodium tetraoxoselenate(VI) poisoning. Köppel C, Baudisch H, Beyer KH, Klöppel I, Schneider V. Two hours after suicidal ingestion of an unknown amount of selenium dioxide, a 17-year-old male was admitted to hospital with asystolia and apnea. Gives off irritating or toxic fumes (or gases) in a fire. Other toxic compounds are selenium dioxide, sodium selenite and selenium sulfide. SELENIUM DIOXIDE Chemwatch: 13839 Version No: 5.1.1.1 Safety Data Sheet according to WHS and ADG requirements Issue Date: 27/06/2017 Print Date: 12/06/2019 S.GHS.AUS.EN SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING Product Identifier Product name SELENIUM DIOXIDE Chemical Name selenium dioxide All rights reserved. Human toxicity from environmental exposure to elemental selenium and selenium salts is rare. 2002 Nov 5;130(1):44-8. doi: 10.1016/s0379-0738(02)00303-1. Acute inhalation exposure to selenium (usually in the form of selenium dioxide or hydrogen selenide) primarily results in respiratory effects with irritation of the mucous membranes in the nose and throat, producing coughing, nosebleeds, dyspnea (difficulty breathing), bronchial spasms, bronchitis, and chemical pneumonia . Journal of Trace Elements in Medicine and Biology, https://doi.org/10.1016/j.jtemb.2019.126435. TRANSPORTATION INFORMATION This product is a regulated material for domestic ground transporation, per CFR Title 49. Ingested doses associated with mortality are in the range of 1–100 mg Se/kg body weight. Selenium is a naturally occurring substance that is toxic at high concentrations but is also a nutritionally essential element. In comparison with its sulfur counterpart ( sulfur hexafluoride ), selenium hexafluoride (SeF 6) is more reactive and is a toxic pulmonary irritant. Sodium selenite is the most toxic compound on oral ingestion. | Acute toxicity - dermal Reason for no classification: data lacking Acute toxicity - inhalation In vitro experiments suggested that trace amounts of hydrogen selenide, which is an intermediate of selenite metabolism, probably induced hemolysis. It plays a role in how your page is seen by search engine crawlers, and how it appears in SERPs 2014 Oct 6;15:388. doi: 10.1186/1745-6215-15-388. © 2019 Elsevier GmbH. Repeated skin exposure can produce local skin destruction, Repeated or prolonged exposure to the substance can produce target organs damage. Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial. This might explain at least part of the discoloration of skin and tissues. Attempts at resuscitation failed and the patient was pronounced dead. Nutrients. NIH Description:Product Description Selenium dioxide is an inorganic compound, chemical formula is SeO2.It is a white crystal, pressure liquefaction can be obtained after the yellow liquid, normal pressure heating to 317℃ sublimation, gre Alvarenga Americano do Brasil PE, Pereira de Souza A, Hasslocher-Moreno AM, Xavier SS, Lambert Passos SR, de Fátima Ramos Moreira M, Santini de Oliveira M, Sperandio da Silva GM, Magalhães Saraiva R, Santos de Aguiar Cardoso C, de Sousa AS, Mediano MF, Bonecini de Almeida Mda G, da Cruz Moreira O, Britto C, de Araújo-Jorge TC. 3 Hazard statement: H301: Toxic if swallowed. Acute toxicity - oral Hazard category: Acute Tox. Ingestion and other exposures to the chemical can cause various symptoms. Toxicity Data: Selenium dioxide LD50 (oral, rat) 68 mg/kg LD50 (subcutaneous, rabbit) 4mg/kg Selenium dioxide is listed by the IARC as Group 3, Unclassifiable (as Selenium and selenium compounds). In cases of severe toxicity, cardiac and pulmonary symptoms may develop and ultimately lead to mortality. SELENIUM DIOXIDE: ICSC: 0946: Selenious anhydride Selenium oxide: March 2000: CAS #: 7446-08-4: UN #: 3283 EC Number: 231-194-7 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Not combustible. Selenium compounds may be absorbed in toxic quantities through the lungs, intestinal tract or damaged skin. Blood levels associated with mortality are above 300 μg Se/L (normal level: 100 μg/L), whereas urinary levels associated with the same endpoint are above170 μg Se/L (normal level: 20–90 μg/L). | Mortality is a risk of acute selenium poisoning. Selenium blood and tissue levels were increased by a factor of 100-1000 as compared to normal. Acute selenium poisoning: suicide by ingestion. Here is a look, courtesy of the Journal of the American Medical Association , at some of the ways selenium toxicity can cause concerns. The substance may be toxic to blood, kidneys, liver, spleen, central nervous system (CNS). Gasmi A, Garnier R, Galliot-Guilley M, Gaudillat C, Quartenoud B, Buisine A, Djebbar D. Forensic Sci Int. DEVELOPMENTAL TOXICITY: Not available. Neurological signs comprise of – irritability, exhaustion, lethargy, decreased mental agility, hand tremors, tingling or loss of sensation in the arms or legs, decreased blood pressure, … Gastrointestinal absorption in animals and humans for various selenium compounds ranges from about 44% to 95% of the ingested dose (Thomson and Stewart, 1974; Bopp et al., 1982; Thomson, 1974). Reacts exothermically with many reducing agents including hydroiodic acid, sulfurous acid, sodium hyposulfite, hydroxylamine salts, hydrazine salts, hypophosphorous acid, phosphorous acid [Merck]. The toxicity depends on the molecular form. Repeated exposure of the eyes to a low level of dust can produce eye irritation. The decreasing order of species sensitivity was: fathead minnow, flagfish, brook trout, channel catfish, goldfish, and bluegill. NLM Selenium dioxide imparts a red colour to glass. Se 8 + 24 F 2 → 8 SeF 6. Trials. Fatal poisoning with selenium dioxide. Copyright © 2021 Elsevier B.V. or its licensors or contributors. D010; A waste containing selenium (such as selenium dioxide) may or may not be characterized a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. The acute toxicity associated with oral selenium ingestion and the blood and urinary levels of selenium in different cases of poisonings were reviewed. We use cookies to help provide and enhance our service and tailor content and ads. Selenium facilitates the lowering of tissue peroxide levels in the body by destroying hydrogen peroxide through the action of the selenium-containing enzyme, glutathione peroxidase. Prevention and treatment information (HHS). Acute (short-term) exposure to elemental selenium, hydrogen selenide, and selenium dioxide by inhalation results primarily in respiratory effects, [Progress in research of the product of the red elemental selenium reduced from selenium oxyanions by bacteria]. Yet at high levels, selenium is toxic, and several cases of overt toxicity and mortality have been reported following acute intoxication. Selenium is not produced in the body, but it is needed for proper thyroid and immune system function. Details of the … The effects of acute selenium poisoning depend upon the route of exposure. Serves as an oxidizing agent. Findings at autopsy included congestion of lungs and kidneys, diffuse swelling of the heart, and brain edema. In case of fire in the surroundings, use appropriate extinguishing media. selenium … Curves relating median lethal concentration to exposure time for each species … Reported symptoms and signs include abdominal symptoms, such as vomiting, diarrhea, pain, and nausea, as well as garlic-like odor on the breath. SELENIUM DIOXIDE reacts with water, particularly hot water, to give selenious (selenous) acid, a weak acid that is corrosive. Exposure to selenious acid or to selenium dioxide can cause serious toxicity (Barceloux, 1999). Acute human toxicity and mortality after selenium ingestion: A review.
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